Document Type : Original research paper
Authors
1
Full Professor, Infectious and Tropical Diseases Research Center, Health Research Institute, Department of Microbiology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
2
Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
3
Department of Oral and Maxillofacial Medicine, School of Dentistry, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
10.22034/hmrj.2023.385582.1077
Abstract
Background: This study aimed to compare the antifungal effects mouthwash herbal on the growth of Candida albicans and Candida glabrata Cinnamol and Jaftex VS two (Matrica and Persica) and Chlorhexidine (as the gold standard).
Methods: Antifungal activities of the mouthwashes regarding Candida albicans and Candida glabrata susceptibility to antifungals were evaluated using the Broth Macrodilution test. The minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) of the mouthwashes were determined thrice. Mouthwashes were compared using the Kruskal-Wallis and Dunn-Bonferroni post hoc test.
Results: Mean MICs for Candida albicans in the case of Chlorhexidine, Jaftex, Persica, Matrica, and Cinnamol were 0.098%, 25.0%, 10.417%, 6.25%, and 3.125%, respectively (p=0.008, excluding Chlorhexidine: p=0.015). Mean MICs for Candida Glabrata in these mouthwashes (in the same order) were 0.067%, 12.50%, 5.208%, 5.208%, and 0.781 (p=0.009, excluding Chlorhexidine: p=0.039). Mean MFCs for Candida albicans were 0.26%, 100%, 12.5%, 8.333%, and 3.125% (p=0.009, excluding Chlorhexidine: p=0.015). Mean MFCs for Candida Glabrata in these mouthwashes were 0.134%, 25.0%, 10.417%, 10.417%, and 1.563%, respectively (p=0.015, excluding Chlorhexidine: p=0.039). MIC and MFC of Candida albicans and Candida Glabrata were different between Jaftex and Chlorhexidine (p≤0.024). After excluding Chlorhexidine, MIC or MFC of Jaftex and Cinnamol were different (p≤0.030).
Conclusion: All mouthwashes showed antifungal activity against Candida albicans and Candida glabrata. Among them, the newly introduced Cinnamon mouthwash exhibited the best antifungal activity against Candida albicans and Candida glabrata, while the experimental herbal mouthwash (Jaftex) was the weakest. Chlorhexidine showed the most potent anti-candida effect compared to herbal mouthwashes.
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