Acute Motor and Sensory Axonal Neuropathy, a Variant of Guillain-Barre Syndrome, Following COVID-19: A Case Report

Document Type : Case report


1 Department of Emergency Medicine, Shoushtar Faculty of Medical Sciences, Shoushtar, Iran

2 Department of Midwifery, Shoushtar Faculty of Medical Sciences, Shoushtar, Iran

3 Student Research Committee Shoushtar Faculty of Medical Sciences, Shoushtar, Iran

4 Department of Neurology. School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran


Introduction: Acute motor and sensory axonal neuropathy (AMSAN) is a variant of Guillain–Barré syndrome (GBS), characterized by acute paralysis and the loss of reflexes and sensory symptoms. The emerging evidence is growing to confirm that SARS‐CoV‐2 infection may be associated with neurological complications, including acute peripheral nerve diseases. Here we reported a case of AMSAN following the COVID-19 diagnosis.
Case presentation:  A 59-year-old man with severe cold symptoms and the oral plague was diagnosed three weeks before the SARS-CoV-2 positive test results. Then the AMSAN disorder was confirmed after hospitalization and more laboratory, clinical, and electrophysiological investigations. However, interestingly, the patient revealed no respiratory symptoms.
Conclusion: GBS can also occur in patients with COVID‐19 without respiratory symptoms. Since GBS syndrome can lead to patient mortality by involving the respiratory system, physicians should identify and treat early GBS and autonomic symptoms in coronavirus-affected individuals to prevent heart and respiratory failure. Accordingly, further studies on the early neurological symptoms of COVID‐19 and their consequences are recommended